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#DS1

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I am currently playing through Dark Souls (remastered) for the first time. Though I have seen playthroughs and played about 1/4 of Elden Ring.

I have beaten the gargoyle's, butterfly, and capra demon so far.

My To Do List

Skeltoons
Blitton / hot spider
Get keys to dank root garden doors.
Slap dragons
Ask hydra politely to leave
Big ass club man

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I hope @tRAJectory hasn't given up his support for Mastodon--he hasn't posted in almost a week--but over on Twitter he shared this chart showing just how much higher ACE2 binding and immune evasive is for #DS1. It is substantially higher for both than XBB.1.5, the current variant spreading in much of the US and Europe. Again, other factors impact a variant's fitness (or how it impacts acute or chronic illness), but with few getting new vaccine jabs in #ireland, this one could hit hard in March.

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If it continues to grow at this pace, #DS1 will become predominant in Ireland right around St. Patrick's Day, a huge event for travel and crowds. Last year's St. Pat's caused #Ireland's 2nd-highest surge of hospitalizations of the #COVID19 pandemic. We could be more cautious as we wait to see what this new variant does, but instead, mass transit, pubs, and events are jammed with maskless people. Living with COVID means accepting illness, disabilities, and hospitalizations.

The new Variant report (2023-02-03) from
@corneliusroemer mentions the #COVID19 variant that is rising in #Ireland. #DS1 may or may not grow to be a significant issue in and outside the nation--we should know within a few weeks if growth persists. It has higher AC2 binding and immune evasion, but while those are important factors, they aren't the only ones that affect a variant's fitness. It is growing at around 40% per week in the past six weeks in Ireland. github.com/neherlab/SARS-CoV-2

GitHubSARS-CoV-2_variant-reports/reports/variant_report_latest_draft.md at main · neherlab/SARS-CoV-2_variant-reportsInformal summaries of notable SARS-CoV-2 lineages. Contribute to neherlab/SARS-CoV-2_variant-reports development by creating an account on GitHub.

No need for alarm (yet) but I'm monitoring a variant's growth here in #Ireland (and so far, nowhere else.) There are too few sequences to sound any alarms, but #DS1 had a 41% weekly growth from Dec19 to Jan16. It'll take weeks to know if this variant will be a concern, but it's worth watching in Ireland for one big reason, St. Patrick's Day, which last year led to the 2nd-highest peak of hospitalizations of the #COVID19 pandemic. At the current rate. DS.1 may become predominant in late March.

#Ireland may have its own #COVID19 variant of interest, found almost nowhere else. It is the very early days and may disappear, but #DS1 (DS.1) seems to be growing rapidly (from 0.79% to 3.72% in a month.) WAY too early to worry about, but if growth continues, it'll get more attention in the coming month. The reason to watch it is that it's both very immune-evasive and has high ACE2 binding--higher for both than XBB.1.5!

Sources: app.powerbi.com/view?r=eyJrIjo

mobile.twitter.com/JPWeiland/s