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Katharina Schmack

: I am obsessed with the biology of and .

I am a at the Francis Crick Institute, London. In our lab, the Collective, we study the neural circuits and immune processes underlying unfounded perceptions and thoughts 🐭 👤 . I look forward to great here!

This is me moving to London without ever having been to London before.

A colorful frog flying over the Atlantic Ocean on a world map following a double helix connecting Cold Spring Harbor Laboratory, New York, with the Francis Crick Institute, London.
Nov 06, 2022, 08:25 AM·Public·Web
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Paul Wicks

@KathaSchmack that is a really cool field of interest! I did my postdoc on non-motor symptoms in Parkinson's disease. While I was meant to be studying depression I got more interested in hallucinations and impulse control disorders. I've only dabbled a little (ALS/MND is my main field) but did support a questionnaire on extra-campine hallucinations (frontiersin.org/articles/10.33) when I was at PatientsLikeMe. Nice to meet you!

FrontiersFifty Percent Prevalence of Extracampine Hallucinations in Parkinson’s Disease PatientsExtracampine hallucinations (EH), the sense of a presence or fleeting movement in the absence of an associated visual percept, have been reported in Parkinson’s disease (PD) patients but their prevalence, characteristics, and temporal relationship to visual hallucinations (VH) remain unclear. Given that, VH are predictive of cognitive impairment in PD, improved understanding of EH may have significant prognostic implications. The objective of this study is to evaluate the prevalence and characteristics of EH in a large unselected population with PD and to assess the temporal relationship between EH, VH, and memory decline. Cross-sectional data were collected from 414 PD patients using a questionnaire circulated via an online patient community. Data were obtained regarding the occurrence, timing, and characteristics of VH and EH and symptoms of PD, disease duration, disease severity, and medication history. About 50.4% of respondents reported EH and 15.5% reported VH. EH were typically experienced alongside, rather than behind, the individual (p < 0.001) without clear lateralization (p = 0.438) and were more likely to be of unfamiliar presences (p < 0.001). The occurrence of EH was associated with Hoehn and Yahr score (p = 0.002) but not disease duration (p = 0.158). EH onset was associated with VH onset (p = 0.046) and occurred after the onset of anosmia (p < 0.001), cognitive decline (p = 0.002), and sleep disturbance (p = 0.002). The reported prevalence of EH in PD patie...
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Joseph Meyer

@KathaSchmack As an adoptive father, caregiver, and advocate for an adult who first began experiencing hallucinations and delusions as young as 4 years of age, I am likewise interested in the study of psychosis as a neurodevelopmental disorder. Thank you for your work in this area.

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SchizoScientist

@KathaSchmack I’m super excited to watch your research results roll in!

I tend to forget to consider the possible mechanistic connections between immune processes and psychosis!

Despite my doctors suggesting that some of my personal history with psychosis might be related to my undiagnosed/untreated celiac disease, I feel like I still too often reach for mechanistic hypotheses involving neurotransmitters (hmm how about my dopamine levels?) instead!

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MedTwitter Expat

@KathaSchmack your research sounds exciting and surprising. Looking forward to more of your posts on here!!

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Matthew Broome

@KathaSchmack @matthewrbroome be interesting in collaborating on delusions if an opportunity!

Quiet public
Katharina Schmack

@matthewrbroome Definitely! As compared to hallucinations, delusions are a little more challenging to study in animal models, but even more fascinating!

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Patrick

@KathaSchmack Telling people you work in the psychosis collective must be interesting at dinner parties I expect?

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Bastiaan van Tol

@KathaSchmack Very fascinating! How are you researching neural circuits underlying psychotic experiences in mice?

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Katharina Schmack

@BastiaanvTol Thanks! We use a cross-species computational psychiatry approach: we develop behavioural tasks and computational models that capture psychosis-like inferences both in humans and in mice. In humans, we relate it to subjective experience (e.g., hallucinations), in mice we relate it to neural circuit activity (e.g., striatal dopamine).

science.org/doi/10.1126/scienc
jamanetwork.com/journals/jamap

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