NerdCulture

0 posts0 participants0 posts today

Danai RigaHappy & proud to share our latest work with the <a href="https://neuromatch.social/tags/bluespot" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bluespot</a> community, <a href="https://neuromatch.social/tags/locuscoeruleus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#locuscoeruleus</a> enthusiasts, and anyone else willing to read 😉<a href="https://www.biorxiv.org/content/10.1101/2023.10.16.562534v1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2023.10.16.562534v1</a>4 years ago, we had the idea that endogenous neuromodulatory systems are in place that control LC activity, thereby promoting adaptive behavioral responses in challenging environments. We examined the role of Neuropeptide Y, as a possible candidate system for this, and identified a new population of <a href="https://neuromatch.social/tags/NPY" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NPY</a>-expressing neurons, distributed in the pericoerulean space. We showed that peri-LC NPY cells innervate the region, providing <a href="https://neuromatch.social/tags/NPY" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NPY</a> input onto <a href="https://neuromatch.social/tags/noradrenergic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#noradrenergic</a> neurons of the LC, and strongly inhibiting their activity, via Y1Rs. Next, we showed that chemogenetic stimulation of NPY cells led to anxiety-relief, via Y1Rs, and conversely, inhibition of NPY neurons triggered an anxiogenic phenotype. Together, we showed a novel role for NPY-mediated <a href="https://neuromatch.social/tags/neuromodulation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuromodulation</a> of the LC in adaptive behaviors. We re happy to hear your thoughts /ideas /feedback on our data. Please share/boost. Happy reading 🔵<a href="https://neuromatch.social/tags/preprint" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#preprint</a> <a href="https://neuromatch.social/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a> <a href="https://neuromatch.social/tags/systemsneuro" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#systemsneuro</a> <a href="https://neuromatch.social/tags/ephys" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ephys</a> <a href="https://neuromatch.social/tags/stress" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#stress</a>

Danai RigaA fantastic day for <a href="https://neuromatch.social/tags/bluespot" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bluespot</a> enthusiasts, with the publication of scRNA seq of the mouse <a href="https://neuromatch.social/tags/LC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#LC</a>.!!The paper goes deep into neuropeptidergic subpopulations within the noradrenergic system, and using galanin (ephys & Ca2+ imaging), exemplifies the countless possibilities of LC neuromodulation by peptidergic signaling. ❤️❤️Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus | PNAS <a href="https://www.pnas.org/doi/10.1073/pnas.2222095120" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.pnas.org/doi/10.1073/pnas.2222095120</a>

Mary C LeggGasteruption jaculator and Blue-Spot Hairstreak, Satyrium spini Canon 7D EFS 60 2.8 f/4.6 1/320 iso: 200 Srbsko, Czech Republic 7/23/2023 <a href="https://ohai.social/tags/Wasps" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Wasps</a> <a href="https://ohai.social/tags/Gasteruption" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Gasteruption</a> <a href="https://ohai.social/tags/parasitoid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#parasitoid</a> <a href="https://ohai.social/tags/BlueSpot" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BlueSpot</a> <a href="https://ohai.social/tags/Satyrium" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Satyrium</a> <a href="https://ohai.social/tags/Lycaenidae" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Lycaenidae</a> <a href="https://ohai.social/tags/butterflies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#butterflies</a> <a href="https://ohai.social/tags/SaveButterflies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SaveButterflies</a> <a href="https://ohai.social/tags/Lepidotera" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Lepidotera</a> <a href="https://ohai.social/tags/Macro" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Macro</a> <a href="https://ohai.social/tags/grasslands" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#grasslands</a>

Danai RigaFantastic resource for the <a href="https://neuromatch.social/tags/bluespot" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bluespot</a> community & noradrenergic research as a whole from the Patriarchi lab, available on AddgeneSensitive multicolor indicators for monitoring norepinephrine in vivo <a href="https://www.nature.com/articles/s41592-023-01959-z" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41592-023-01959-z</a>Dreaming about all the cool fiber photometry experiments that are possible now!! 🔵🔵

Danai RigaPlugging here for fellow <a href="https://neuromatch.social/tags/bluespot" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bluespot</a> member & <a href="https://neuromatch.social/tags/locuscoeruleus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#locuscoeruleus</a> enthusiast, Greyson Sipe:"the Sipe lab officially started at Penn State in March, 2023 and we are actively recruiting graduate students and postdoctoral fellows! Please feel free to spread the news to anybody interested in studying neurons, astrocytes, and neuromodulators in arousal, stress and addiction. The lab is pretty much set up with a cutting-edge 2-photon microscope, a custom 1-photon widefield scope, two dual-color fiber photometry rigs, and a suite of behavioral rigs with optogenetics (mini-scopes are on the way)".For inquiries check: <a href="https://www.sipelab.com/openings" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sipelab.com/openings</a>

Danai RigaA series of extremely cool <a href="https://nerdculture.de/tags/locuscoeruleus" class="mention hashtag" rel="tag">#locuscoeruleus</a> manuscripts have been put out there recently, and I wanna take the opportunity to highlight them in this🧵 Would love input from other <a href="https://nerdculture.de/tags/bluespot" class="mention hashtag" rel="tag">#bluespot</a> enthusiasts, since I'm definitely missing papers! Maybe we can keep adding by replying, and eventually create an easily accessible list of publications that currently shape the <a href="https://nerdculture.de/tags/LC" class="mention hashtag" rel="tag">#LC</a> field🔵<a href="https://nerdculture.de/tags/systemsneuro" class="mention hashtag" rel="tag">#systemsneuro</a> <a href="https://nerdculture.de/tags/neuroscience" class="mention hashtag" rel="tag">#neuroscience</a> <a href="https://nerdculture.de/tags/noradrenaline" class="mention hashtag" rel="tag">#noradrenaline</a> <a href="https://nerdculture.de/tags/preprints" class="mention hashtag" rel="tag">#preprints</a>

Mareike LudwigI am fascinated by the <a href="https://mastodon.world/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brain</a> 🧠, <a href="https://mastodon.world/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a>, <a href="https://mastodon.world/tags/ageing" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ageing</a>, <a href="https://mastodon.world/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimer</a>'s <a href="https://mastodon.world/tags/dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dementia</a> and <a href="https://mastodon.world/tags/neurodegenerative" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neurodegenerative</a> <a href="https://mastodon.world/tags/diseases" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#diseases</a> - especially the <a href="https://mastodon.world/tags/noradrenergic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#noradrenergic</a> system of the <a href="https://mastodon.world/tags/LocusCoeruleus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#LocusCoeruleus</a> ( <a href="https://mastodon.world/tags/LC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#LC</a> <a href="https://mastodon.world/tags/bluespot" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bluespot</a> 🔵🔵) and <a href="https://mastodon.world/tags/vagusnervstimulation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#vagusnervstimulation</a> ⚡. Let's continue to exchange about it.

Recent searches

Search options

Administered by:

Server stats:

#bluespot