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3 posts2 participants0 posts today
Stephan Hacker<p>The flash talk session and the posters were a highlight of <a href="https://mstdn.science/tags/ABPP2025" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ABPP2025</span></a>. We heard a lot of exciting research into <a href="https://mstdn.science/tags/covalent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>covalent</span></a> <a href="https://mstdn.science/tags/fragment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>fragment</span></a> screening, <a href="https://mstdn.science/tags/antibiotic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>antibiotic</span></a> development, <a href="https://mstdn.science/tags/microbiome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microbiome</span></a> activities, posttranslational modifications <a href="https://mstdn.science/tags/PTMs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PTMs</span></a> and lysine-directed <a href="https://mstdn.science/tags/kinase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>kinase</span></a> inhibitors.<br><a href="https://mstdn.science/tags/ABPP" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ABPP</span></a> <a href="https://mstdn.science/tags/Chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Chemistry</span></a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a></p>
Stephan Hacker<p>Making better use of available data is an important way to make drug discovery more efficient.</p><p>In his <span class="h-card" translate="no"><a href="https://mstdn.science/@LED3hub" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>LED3hub</span></a></span> John Overington talked about the power of data to speed up the drug discovery process.</p><p><a href="https://mstdn.science/tags/chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemistry</span></a> <a href="https://mstdn.science/tags/DrugDiscovery" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DrugDiscovery</span></a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> <a href="https://mstdn.science/tags/DataScience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DataScience</span></a><br>(1/9)</p>
Stephan Hacker<p>Looking forward to the <a href="https://mstdn.science/tags/ABPP2025" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ABPP2025</span></a> meeting in London starting this weekend. An amazing lineup of world-leading speakers in the field from academia and industry!</p><p>If you are there on Saturday or Sunday morning and want to catch up, send me a message!</p><p><a href="https://mstdn.science/tags/ABPP" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ABPP</span></a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a></p><p><a href="https://www.eventcreate.com/e/abpp2025/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">eventcreate.com/e/abpp2025/</span><span class="invisible"></span></a></p>
Stephan Hacker<p>Lipidation of proteins has diverse essential roles in biology.</p><p>In his amazing keynote lecture at <a href="https://mstdn.science/tags/Lunteren" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Lunteren</span></a>, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using <a href="https://mstdn.science/tags/ChemicalProteomics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemicalProteomics</span></a>. (1/5)<br><a href="https://mstdn.science/tags/chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemistry</span></a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a></p>
Stephan Hacker<p>Great keynote lecture by Marta Artola of the <span class="h-card" translate="no"><a href="https://mstdn.science/@LED3hub" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>LED3hub</span></a></span> at <a href="https://mstdn.science/tags/Lunteren" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Lunteren</span></a>. She talked about the importance of glycosidases in various diseases and her great work on conformationally locked <a href="https://mstdn.science/tags/covalent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>covalent</span></a> and non-covalent <a href="https://mstdn.science/tags/inhibitors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>inhibitors</span></a> and <a href="https://mstdn.science/tags/probes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>probes</span></a>.<br><a href="https://mstdn.science/tags/chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemistry</span></a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a><br><a href="https://pubs.acs.org/doi/10.1021/jacs.2c05666" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pubs.acs.org/doi/10.1021/jacs.</span><span class="invisible">2c05666</span></a></p>
LED3hub<p>We are very happy that Marta Artola represented our network at the <a href="https://mstdn.science/tags/Lunteren" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Lunteren</span></a> meeting of the Divisions <a href="https://mstdn.science/tags/SOC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SOC</span></a> and <a href="https://mstdn.science/tags/MCCB" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MCCB</span></a> of the KNCV. She talked about "Conformationally Locked Glycosidase Inhibitors, Probes and Degraders".<br><a href="https://mstdn.science/tags/chemsky" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemsky</span></a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a><br><a href="https://pubs.rsc.org/en/content/articlelanding/2023/sc/d3sc05016e" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pubs.rsc.org/en/content/articl</span><span class="invisible">elanding/2023/sc/d3sc05016e</span></a></p>
Sam Levine<p>I have no idea how competitive this is (maybe they only get 10 applicants? maybe they get 10,000?) but it might be worth having grad students apply since it looks like the initial application is only a total of 375 words. No cash, but $5,000 in qiagen supplies is nothing to sneeze at either.</p><p><a href="https://www.qiagen.com/us/applications/molecular-biology-research/my-science/young-scientist-grant#apply" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">qiagen.com/us/applications/mol</span><span class="invisible">ecular-biology-research/my-science/young-scientist-grant#apply</span></a></p><p><a href="https://neuromatch.social/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> <a href="https://neuromatch.social/tags/Biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Biology</span></a> <a href="https://neuromatch.social/tags/Chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Chemistry</span></a> <a href="https://neuromatch.social/tags/ChemiVerse" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemiVerse</span></a> <a href="https://neuromatch.social/tags/Research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Research</span></a></p>
Stephan Hacker<p>In my <a href="https://mstdn.science/tags/Antibiotics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Antibiotics</span></a> Master's course, we have student presentations with papers that they identify from the literature based on a broad topic they are given. This is always a highlight of the course with many interesting papers presented. I will post this year's selection. <a href="https://mstdn.science/tags/chemsky" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemsky</span></a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a></p>
Stephan Hacker<p>Do you want to present your research to a broad global audience?</p><p>Then you should check out, <a href="https://mstdn.science/tags/RSCPoster" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>RSCPoster</span></a>, which will happen on March 4th to 5th. Very excited to chair the <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> part <a href="https://mstdn.science/tags/RSCChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>RSCChemBio</span></a> together with Lyn Jones and Ali Tavassoli.</p><p>Click this link for all information: <a href="https://www.rsc.org/our-events/rsc-poster/#about-rsc-poster" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">rsc.org/our-events/rsc-poster/</span><span class="invisible">#about-rsc-poster</span></a></p>
Ellis Crawford<p>Nominations for the new Chemical Science lectureship are open!</p><p>We're looking for researchers in imaging, biosensing, and diagnostics, which aligns with the <a href="https://fediscience.org/tags/ChemSciSymposium" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemSciSymposium</span></a>, that have published in Chemical Science in the last 5 years.</p><p>Nominate at <a href="https://rsc.li/chemsci-lectureship25" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">rsc.li/chemsci-lectureship25</span><span class="invisible"></span></a></p><p><a href="https://fediscience.org/tags/Chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Chemistry</span></a> <a href="https://fediscience.org/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a></p>
Stephan Hacker<p>Do you want to present your research to a broad global audience?</p><p>Then you should check out, <a href="https://mstdn.science/tags/RSCPoster" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>RSCPoster</span></a>, which will happen on March 4th to 5th. Very excited to chair the <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> part <a href="https://mstdn.science/tags/RSCChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>RSCChemBio</span></a> together with Lyn Jones and Ali Tavassoli.</p><p>Click this link for all information: <a href="https://www.rsc.org/our-events/rsc-poster/#about-rsc-poster" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">rsc.org/our-events/rsc-poster/</span><span class="invisible">#about-rsc-poster</span></a></p>
Sam Levine<p>Where are my biologist friends...</p><p>If you have an enzyme with a "lag" before it starts activity can you still do initial rate and assume Michaelis-Menten kinetics from whenever it actually starts? (in this case it's working on a chromogenic substrate to "easy" to monitor when it starts)</p><p><a href="https://neuromatch.social/tags/ChemicalBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemicalBiology</span></a> <a href="https://neuromatch.social/tags/Biochemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Biochemistry</span></a> <a href="https://neuromatch.social/tags/Biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Biology</span></a> <a href="https://neuromatch.social/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> <a href="https://neuromatch.social/tags/EnzymeKinetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EnzymeKinetics</span></a></p>
Stephan Hacker<p>Great talk by Arnaud Gautier at <a href="https://mstdn.science/tags/EFMCISCB25" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EFMCISCB25</span></a>. He talked about his group's work on the CATCHFIRE technology, that allows chemical induction of protein (hetero)dimerization with simultaneous production of a fluorescent signal to monitor the dimerization. <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> <a href="https://mstdn.science/tags/chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemistry</span></a> <a href="https://www.nature.com/articles/s41592-023-01988-8" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41592-023</span><span class="invisible">-01988-8</span></a></p>
Stephan Hacker<p>The last day of <a href="https://mstdn.science/tags/EFMCISCB25" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EFMCISCB25</span></a> by the EFMC is off to a great start with an insightful keynote lecture by Cynthia Burrows. She talked about the use of nanopore sequencing to characterize chemically modified nucleotides in RNA. <a href="https://mstdn.science/tags/chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemistry</span></a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> <a href="https://pubs.acs.org/doi/10.1021/acscentsci.1c00788" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pubs.acs.org/doi/10.1021/acsce</span><span class="invisible">ntsci.1c00788</span></a></p>
Stephan Hacker<p>Great talk by Mario van der Stelt at <a href="https://mstdn.science/tags/EFMCISCB25" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EFMCISCB25</span></a>. He talked about his group’s exciting research within the LED3hub and the Institute for Chemical Neuroscience (iCNS) consortium on chemical neuroscience. Great insights, how chemical tools and <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> methods can shed new light onto the processes in the brain. (1/3)</p>
Stephan Hacker<p>Great talk by Kai Johnsson at <a href="https://mstdn.science/tags/EFMCISCB25" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EFMCISCB25</span></a>. He talked about his group’s work on recording transient cellular events for post hoc analysis. Great <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> tools that allow to better understand quick events like those in neuronal communication. (1/5) <a href="https://www.science.org/doi/10.1126/science.adg0812" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/10.1126/scienc</span><span class="invisible">e.adg0812</span></a></p>
Stephan Hacker<p>Exchange between academia and industry is important to drive our academic discoveries towards societal impact.</p><p>Excited to be at the EFMC <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> Industry Interest Group meeting at the impressive site of Roche in Basel today to exchange with leaders of various companies.</p>
Stephan Hacker<p>Great talk by Slava Ziegler at <a href="https://mstdn.science/tags/AdvancesChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AdvancesChemBio</span></a>. She talked about the identification of IDO1 binders based on pseudo-natural products. Interesting insights, that the hit iDeg-1 leads to supercharged degradation of IDO1 through its native E3 KLHDC3. <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> <a href="https://mstdn.science/tags/chemsky" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemsky</span></a> <a href="https://www.biorxiv.org/content/10.1101/2024.07.10.602857v3" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.07.10.602857v3</span></a></p>
Stephan Hacker<p>The human gut microbiome plays a huge role in human health and disease.<br>Markus Lakemeyer talked at <a href="https://mstdn.science/tags/AdvancesChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AdvancesChemBio</span></a> about his exciting research into using an integrated <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> approach to better understand protease activity in bacteria of the microbiome. <a href="https://www.biorxiv.org/content/10.1101/2025.01.15.633241v1.full" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">25.01.15.633241v1.full</span></a></p>
Stephan Hacker<p>Interesting talk by Clemens Richert at the <a href="https://mstdn.science/tags/AdvancesChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AdvancesChemBio</span></a>. He talked about his group's research on modified nucleoside monophosphates including ProTide-like prodrugs that do not require the HINT enzymes for activation. <a href="https://mstdn.science/tags/chemsky" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemsky</span></a> <a href="https://mstdn.science/tags/ChemBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ChemBio</span></a> <a href="https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202319958" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">onlinelibrary.wiley.com/doi/pd</span><span class="invisible">f/10.1002/anie.202319958</span></a></p>
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